Acute to chronic pain are both considered to be a silent epidemic. Chronic pain affects approximately 50% of EU residents, with most of them not receiving adequate treatment. Undertreated and untreated pain profoundly affects the quality of life and affects physical, social, and psychological aspects.

Inappropriately managed pain can also lead to immunological and neural alterations in an individual, leading to chronic pain if left untreated. However, the creation and marketing of an effective pain management tool, Zamadol, has allowed these patients to receive safe, yet reliable results.

High medical bills and inadequate relief can be put to rest, as this medication is affordable and effective. Due to its impressive qualities, it has progressed worldwide and promises all its users effective results with every dose.

What is Zamadol?

Zamadol belongs to the category of opioid analgesics as it contains the active ingredient tramadol hydrochloride. The latter was originally created in 1963 and was patented in 1977. This inhibited the creation of similar competing painkillers, at the time.

It was approved in the mid-1990s in Europe, where patients began to buy tramadol 50 mg. When the patent expired in 2003, it gave way for medications such as Zamadol to be created. The medication successfully treats pain of different intensities in any part of the body.

It mainly performs its pain-relieving effects through the central nervous system; hence it is considered a 'central painkiller'. When the term opioid is brought up, patients immediately become cautious as it has a high risk of addiction and dependency.

Potent opioids make some patients feel as if it is necessary for survival, and they become tolerant with each dose, leading to higher doses. However, Zamadol does not produce these risks. It is safer than conventional opioid painkillers while providing the same effective pain-relieving effects. The active ingredient present in the medication is said to be one-tenth the potency of morphine.

Due to this impressive set of characteristics, the medication can safely be used in adults and the elderly. The patient can take it in the lowest effective dose and combine it with non-steroidal anti-inflammatory medications for a higher level of pain relief.

Zamadol can successfully treat:

  • Acute and chronic pain
  • Lower back pain (acute or chronic)
  • Pain after operation
  • Fibromyalgia
  • Painful and tender muscles
  • Nerve pain
  • Arthritis and osteoarthritis

A study showed that the medication is well-tolerated in all age groups as it has a dual nature of action in the body.

Zamadol Active Ingredient

Zamadol contains the same active ingredient as the original brand, which is also responsible for its effective mechanism of relieving pain. Although it is synthetic, it was designed to structurally match the effects of natural opioids. However, Zamadol differs slightly from natural opioids as it works in two ways.

These two mechanisms are:

  • Opioid agonist
  • Inhibitory effect on neurotransmitters, norepinephrine and serotonin

The active ingredient activates pain inhibitory pathways in the body and consists of two components that benefit its pain-relieving characteristics. The primary component, O-desmethyl-tramadol, attaches to opioid receptors in the brain to intercept the impulse of pain.

The other component inhibits the reuptake of norepinephrine and serotonin. This classifies the medication as a weak anti-depressant due to this SNRI ability. It is one of the reasons behind the treatment's unique tolerance profile.

This is called a dual-acting mechanism of action, where both processes are corresponding, which overall improves pain control. Additionally, these mechanisms are shown to affect pain modulators in the central nervous system.

Patients that buy painkillers in the EU will benefit from the broad range of targets that Zamadol can attain. This is why it is effective in almost all pain types, from labour pain to back pain. Additionally, the SNRI property reduces anxiety and shivering, which are expected negatives associated with pain.

Zamadol Duration of Effects

When patients buy tramadol in the EU, they will notice that the medication is commonly available in two formulations, fast-acting and extended-release. These formulations make it convenient for patients who have different types and severities of pain. Zamadol is also available in these formulations.

Short-acting medication is effective as soon as it is administered, and it needs regularly repeated equal doses if used long-term. This treatment is usually taken four times a day, every 4 to 6 hours. Extended-release medication uses a special technology that disintegrates the tablet slowly over 12 to 24 hours.

This allows patients more extended relief, and the medication does not require multiple doses throughout the day. In pain control, this formulation is beneficial as it provides longer durations of relief without repeated doses.

Due to these two formulations, the duration of Zamadol depends on the formulation that the patient is taking.

The durational effects are as follows:

  • Fast-acting- They begin to work within one hour and reaches their peak concentrations in 2 hours. These effects last for 4 to 6 hours, which requires patients to take timed doses during the day. This form is best for acute pain and those who need instant relief.
  • Extended-release- They begin to work gradually over 12 to 24 hours. This eliminates the need for multiple doses during the day. Patients should not be discouraged with this timeframe and take another dose as it is designed to produce gradual pain relief. It should only be taken once daily. This is best-equipped for chronic pain and those who use it long-term.

Zamadol Dosage Guide

Since Zamadol is available in two forms, the dosage guide differs for them both. This is due to the time that is taken for each form to produce its effects. However, these forms do not vary in their potency, tolerance and safety profiles.

To guarantee a positive experience from this treatment, it is encouraged to follow a strict dosage routine. Deducing a routine assists patients with taking their doses without forgetting or repeating a dose.

A general dosing plan is as follows:

1. Fast-acting

  • Acute pain - 50mg to 100mg single dose taken every 4 to 6 hours. Patients are advised to take it as soon as they feel pain. It can be used on an as-needed basis.
  • Chronic pain - Initial dose of 25mg taken every morning, four times throughout the day. After evaluating the response, the dosage can be increased to 50mg to 100mg if needed.

2. Extended-release

  • Chronic pain - The dose can be initiated at 100mg, taken once daily. It can be increased every five days by 100mg if required.
what is tramadol

Zamadol Side Effects

The Zamadol side effects are prevalent with almost all users of the medication, however, they do not have a severe expression. This allows patients to manage any side effects with simple at-home remedies which do not require additional medications.

Compared to conventional opioids, this medication has lessened side effects. One is prone to side effects if:

  • First-time user of the medication.
  • Unnecessary alteration of the dose.
  • Sudden discontinuation of the treatment.

However, these side effects are reported to affect 1% of Zamadol users and include:

  • Headache
  • Nausea
  • Bitter taste/dry mouth
  • Dizziness
  • Drowsiness
  • Weakness

Are Opioids Like Zamadol Safe?

Medical experts are always looking for a newer, safer treatment to relieve pain. This search has become desperate as opioid abuse has reached epidemic status. One substance that came out of this search for effective and safe painkillers, an artificial opioid called Zamadol. This medication has been marketed as a safe, non-addictive pain killer.

It is said that it has a 30% higher tolerance compared to other natural opioids. This is advantageous in patients who require potent painkillers all the time, as they do not have to worry about the intermittent risk of tolerance and dependence.

Zamadol safely produces these effects:

  • Pain control
  • Muscle-relaxant
  • Promotion of sleep
  • Improved mood
  • Weak anti-depressant

More About Zamadol in the EU

The broad spectrum of effects that Zamadol produces allows patients to use this medication for various types of pain and discomfort. This medication also has many other benefits, such as:

  • An excellent absorption rate when ingested.
  • The concurrent use of other low-level pain medications in conjunction with Zamadol.
  • The availability of pills and capsules makes administration convenient for those with a physical or psychological problem with pills.
  • Fertility of both genders is not affected by the use of the tablet.
  • It can be taken before or after a meal.
  • It is easily attainable from trusted online sources.

Buy Zamadol in the EU

Searching for an effective pain solution can become challenging and may eventually cause anxiety due to patients not managing their pain. Most local dispensaries only stock painkillers, which gives temporary relief, leaving patients with inadequate treatment. Add to this very high prices and lengthier processes.

However, there is now an opportunity to safely buy tramadol online in the EU. Painkillers such as Zamadol can be obtained from trusted online sources, such as our website. Patients have the chance to raise any concerns or questions regarding the medication via our customer service portal.

The order process does not take more than 5 minutes, and packages are dispatched to you in not more than a day following confirmation. Patients no longer have to fervently search for painkillers - one can simply visit our website to purchase Zamadol at

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